mendelian randomization studies Actionable

Mendelian randomization using a genetic variant that associates with... | Download Scientific Diagram

Actionable druggable genome-wide Mendelian …

 · We found significant Mendelian randomization results for three proteins (ACE2, P = 1.6 × 10−6; IFNAR2, P = 9.8 × 10−11 and IL-10RB, P = 2.3 × 10−14) using cis-expression quantitative
Framework of a Mendelian randomization study in its most basic... | Download Scientific Diagram

Efficient Design for Mendelian Randomization Studies: Subsample Instrumental Variable Estimators

 · PDF 檔案Mendelian randomization (MR) is a study design used to test or estimate the causal relationship between an exposure and an associated outcome using data on inherited genetic variants that influence exposure status (1, 2). Because associations between
Mendelian randomization studies of biomarkers and type 2 diabetes in: Endocrine Connections Volume 4 Issue 4 (2015)

METHODOLOGY Power and sample size calculations for Mendelian randomization studies using one …

 · PDF 檔案Mendelian randomization, which is instrumental variable analysis using genetic variants as instruments, is an increasingly popular method of making causal inferences from observational studies. In order to design efficient Mendelian randomization studies, it is
Using Mendelian Randomization to Decipher Mechanisms of Bone Disease | SpringerLink

Smoking and COVID-19: A two-sample Mendelian …

 · Evidence from observational studies suggested that smokers are at increased risk of coronavirus disease 2019 (COVID-19). We aimed to assess the causal effect of smoking on risk for COVID-19 susceptibility and severity using two-sample Mendelian randomization method. Smoking-associated variants were
IJERPH | Free Full-Text | Usefulness of Mendelian Randomization in Observational Epidemiology | HTML

Plasma cortisol and risk of atrial fibrillation: A Mendelian …

 · Researchers used a two-sample Mendelian randomization (MR) design to ascertain if there exists a causal link of plasma cortisol with atrial fibrillation (AF). In the CORtisol NETwork consortium (12 597 participants), three genetic variants in the SERPINA1/SERPINA6 locus and functionally related to plasma cortisol were detected.
Scheme of randomized controlled trial and Mendelian randomization... | Download Scientific Diagram

STROBE-MR: Guidelines for strengthening the reporting of Mendelian randomization studies

 · PDF 檔案Mendelian randomization studies While the number of studies using Mendelian randomization (MR) methods has grown exponentially in the last decade, the quality of reporting of these studies often has been poor. Similar to other reporting guidelines such as
Two-step Mendelian randomization framework considering epigenetic... | Download Scientific Diagram

Which Risk Factors Causally Influence Dementia? A …

To systematically review Mendelian randomization (MR) studies investigating causal relationships between risk factors and global cognitive function or dementia. Methods: We searched five databases from inception to February 2017 and conducted citation searches including MR studies investigating the association between any risk factor and global cognitive function, all-cause dementia or
A Mendelian Randomization Study of Plasma Homocysteine and Multiple Myeloma | Scientific Reports

Mendelian randomization: use of genetics to enable causal inference in observational studies

 · PDF 檔案Mendelian randomization: use of genetics to enable causal inference in observational studies Marion Verduijn 1 , Bob Siegerink 1 , Kitty J. Jager 2 , Carmine Zoccali 3 and Friedo W. Dekker 1
(PDF) Mendelian randomization: Use of genetics to enable causal inference in observational studies

Testing for causality between systematically identified …

 · Using Mendelian randomization (MR), we assessed whether associations of 36 reported glioma risk factors showed evidence of a causal relationship. We performed a systematic search of MEDLINE from inception to October 2018 to identify candidate risk factors and conducted a meta-analysis of two glioma genome-wide association studies (5739 cases and 5501 controls) to form our …
Mendelian randomisation in cardiovascular research: an introduction for clinicians | Heart

Genetically Proxied Inhibition of Coagulation Factors and …

 · Background We conducted Mendelian randomization analyses investigating the linear associations of genetically proxied inhibition of different coagulation factors with risk of common cardiovascular Science Volunteer
Using Mendelian Randomization to Decipher Mechanisms of Bone Disease | SpringerLink

Mendelian Randomization: New Applications in the …

Table 1 -Examples of recent Mendelian randomization studiesTable 2 -Potential pitfalls in Mendelian randomization studiesTable 3 -Alignment between Mendelian randomization (MR) studies and randomized controlled trials (RCTs)Table 4 -Publicly available …
Principles of Mendelian randomization analysis and assumptions that... | Download Scientific Diagram
Mendelian Randomization
Introduction In this chapter, we consider extensions to a simple Mendelian randomization analysis to include data from multiple studies. We provide methods for combining the information provided by each study in an efficient way to produce a single causal estimate.
Mendelian randomisation in cardiovascular research: an introduction for clinicians | Heart

Genetically determined blood pressure, antihypertensive …

 · A novel method for estimating causal effects of risk factors in observational studies using genetic variants is Mendelian randomization (MR) []. Due to the random assortment of genes at conception, MR overcomes the core shortcomings of observational studies and assesses lifelong exposures to risk factors, and thus, it can clarify potential causal associations [ 6 ].
Algorithm for using Mendelian randomization (MR) studies to the anticipate results of randomized trials.

Mendelian Randomization Studies Promise to Shorten …

Mendelian Randomization Studies Promise to Shorten the Journey to FDA Approval @article{Roberts2018MendelianRS, title={Mendelian Randomization Studies Promise to Shorten the Journey to FDA Approval}, author={R. Roberts}, journal={JACC: Basic to Translational Science}, year={2018}, volume={3}, pages={690 – 703} }
Mendelian randomization: can genetic epidemiology help redress the failures of observational epidemiology? | SpringerLink

Genetic predisposition to smoking is associated with risk …

 · Here, we applied the Mendelian randomization (MR) approach to examine the potential causal relationship between smoking and risk of RA. Summary statistics data for RA were obtained from a meta-analysis of genome-wide association studies (GWAS), including 14,361 RA cases and 43,923 controls of European ancestry.